Blar i forfatter "Timmerhaus, Gerrit"

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    • Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes 

      Wessel, Øystein; Krasnov, Aleksei; Timmerhaus, Gerrit; Rimstad, Espen; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-16)
      Salmonid red blood cells are the main target cells for <i>Piscine orthoreovirus</i> (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (<i>Salmo salar</i>), Chinook salmon (<i>Onchorhynchus tshawytscha</i>), Coho salmon (<i>Oncorhynchus kisutch</i>), rainbow trout (<i>Onchorhynchus mykiss</i>) and brown trout (<i>Salmo trutta</i>), and can cause diseases like heart and skeletal muscle ...

    • The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense 

      Gjessing, Mona Cecilie; Krasnov, Aleksei; Timmerhaus, Gerrit; Brun, Svante; Afanasyev, Sergey; Dale, Ole Bendik; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-04)
      The salmon gill poxvirus (SGPV) is a large DNA virus that infects gill epithelial cells in Atlantic salmon and is associated with acute high mortality disease outbreaks in aquaculture. The pathological effects of SGPV infection include gill epithelial apoptosis in the acute phase of the disease and hyperplasia of gill epithelial cells in surviving fish, causing damage to the gill respiratory surface. ...

    • The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense 

      Gjessing, Mona Cecilie; Krasnov, Aleksei; Timmerhaus, Gerrit; Brun, Svante; Afanasyev, Sergey; Dale, Ole Bendik; Dahle, Maria K (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-04)
      The salmon gill poxvirus (SGPV) is a large DNA virus that infects gill epithelial cells in Atlantic salmon and is associated with acute high mortality disease outbreaks in aquaculture. The pathological effects of SGPV infection include gill epithelial apoptosis in the acute phase of the disease and hyperplasia of gill epithelial cells in surviving fish, causing damage to the gill respiratory surface. ...

    • Mucosal and systemic physiological changes underscore the welfare risks of environmental hydrogen sulphide in post-smolt Atlantic salmon (Salmo salar) 

      Lazado, Carlo C.; Stiller, Kevin Torben; Timmerhaus, Gerrit; Reiten, Britt Kristin Megård; Nicolaysen, Ilona Lorraine; Carletto, Danilo; Alipio, Hanna Ross De Dios; Hansen-Bergstedt, Julie; Andersen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)
      Atlantic salmon (Salmo salar) might encounter toxic hydrogen sulphide (H<sub>2</sub>S) gas during aquaculture production. Exposure to this gas can be acute or chronic, with heightened levels often linked to significant mortality rates. Despite its recognised toxicity, our understanding of the physiological implications of H<sub>2</sub>S on salmon remains limited. This report details the mucosal and ...

    • Oxidant-induced modifications in the mucosal transcriptome and circulating metabolome of Atlantic salmon 

      Lazado, Carlo C.; Pedersen, Lars-Flemming; Kirste, Katrine H.; Soleng, Malene; Breiland, Mette Serine Wesmajervi; Timmerhaus, Gerrit (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-06)
      Here we report the molecular networks associated with the mucosal and systemic responses to peracetic acid (PAA), a candidate oxidative chemotherapeutic in Atlantic salmon (<i>Salmo salar</i>). Smolts were exposed to different therapeutic doses (0, 0.6 and 2.4 mg/L) of PAA for 5 min, followed by a re-exposure to the same concentrations for 30 min 2 weeks later. PAA-exposed groups have higher external ...

    • Peracetic acid as a potential treatment for amoebic gill disease (AGD) in Atlantic salmon - Stage 1 

      Lazado, Carlo C.; Timmerhaus, Gerrit; Pedersen, Lars-Flemming; Pittman, Karin; Soleng, Malene; Haddeland, Sindre; Johansen, Lill-Heidi; Breiland, Mette Serine Wesmajervi; Rørmark, Lisbeth; Mohammad, Saima; Hytterød, Sigurd (Research report; Forskningsrapport, 2019-06)
      PERAGILL is an initiative that ultimately aims to develop an alternative treatment for the currently available therapies for amoebic gill disease (AGD) that have several practical and environmental issues. Peracetic acid (PAA) is a potent oxidant with a broad spectrum of antimicrobial activity and decays into relatively safe residuals, thus, has been widely recognised as a sustainable disinfectant ...